The Flagstaff-Grand Canyon Stage Route, used from 1892 to 1901, was one of the most popular routes to the Grand Canyon. In addition to commercial stage coaches, it was also used by private coaches and horseback riders. This road angled northwest out of Flagstaff and ended at the Grandview Hotel on Grandview Point, inside what is now Grand Canyon National Park. One of the three stage stops enroute was at Moqui Tanks. Water was probably hauled here from Cedar Ranch, another stage stop, and stored in a cistern which is still evident at the site. In 1894, two area sheepmen settled a disagreement at Moqui Tanks with a shootout in which one of the sheepman was killed. The resulting chase led the local sheriff all the way to New Mexico.

At the Moqui Station, a change of horses was made and passengers rested from what was undoubtedly a very bumpy and dusty ride. Remains of old buildings can be seen here. The day-long trip was made in a four to six horse stage, with a second coach attached if necessary. The cost was $20.00, a considerable sum in those days. When the Grand Canyon Railroad was completed to the South Rim from Williams in 1901, passengers gladly abandoned the dusty and bumpy stagecoach for the railroad, and the stage line became a thing of the past.